Department of Cellular and Molecular Immunology

Chairman: Professor Xintai Zhao, Ph.D.
Staffs: 13 (faculty members: 7, employees: 2, master students: 4)

Tumor target molecules are investigated and their applications in diagnosis and biological therapy for cancer are explored by means of the techniques of cellular biology, molecular biology and molecular immunology. The platforms with high throughput and efficiency for production of monoclonal antibodies and human antibodies are been establishing. Diagnostic methods and targeted therapy for cancer will be developed base on the antibody.

Several on-going projects supported by National “863” Program, National Natural Science Foundation, Shanghai Municipality and Shanghai Municipal Bureau of Public Health are as following, e.g. diagnosis and therapy using mAbs for small cell lung cancer, construction of human antibody library with high titer, establishment of techniques for human antibodies with high affinity, screening and identification of antigen gene of 2F7 mAb of small cell lung cancer, construction and function of a diabody of 2F7 antibody against small cell lung cancer and the antibody against CD3, the function of hepatocellular carcinoma suppressor 1 (HCCS1), and so on.

Diagnostic kit of radio-immuno-imaging for small cell lung cancer has been approved by SFDA for a clinical trial. A number of prizes had been awarded by the Shanghai Science and Technology Progress (Grade II and Grade III) for several finished projects of the Department.